Development and First Validation of a Disease Activity Score for Gout.

ABSTRACT:

Objective

To develop a new composite disease activity score for gout and provide its first validation.

Methods

Disease activity has been defined as the ongoing presence of urate deposits that lead to acute arthritis and joint damage. Every measure for each Outcome Measures in Rheumatology core domain was considered. A 3-step approach (factor analysis, linear discriminant analysis, and linear regression) was applied to derive the Gout Activity Score (GAS). Decision to change treatment or 6-month flare count were used as the surrogate criteria of high disease activity. Baseline and 12-month followup data of 446 patients included in the Kick-Off of the Italian Network for Gout cohort were used. Construct- and criterion-related validity were tested. External validation on an ind

SUBMITTER: Scire CA 

PROVIDER: S-EPMC5129490 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature