Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis.

ABSTRACT:

Objective

To use statistical methods to establish a threshold for individual response in patient-reported outcomes (PROs) in patients with rheumatoid arthritis.

Methods

We used an analysis of variance model in patients on stable therapy (discovery cohort) to establish critical differences (d_crit ) for the minimum change associated with a significant individual patient response (beyond normal variation) in the PRO measures of pain (0-10), fatigue (0-10), and function (Funktionsfragebogen Hannover questionnaire; 0-100). We then evaluated PRO responses in patients initiating adalimumab in a noninterventional study (treatment cohort).

Results

In the discovery cohort (n = 700), PROs showed excellent long-term retest reliability. The minimum change that exceeded

SUBMITTER: Scharbatke EC 

PROVIDER: S-EPMC5129502 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature