Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.

ABSTRACT:

Aims

To assess the safety of buprenorphine compared with methadone to treat pregnant women with opioid use disorder.

Methods

We searched PubMed, Embase and the Cochrane Library from inception to February 2015 for randomized controlled trials (RCT) and observational cohort studies (OBS) that compared buprenorphine with methadone for treating opioid-dependent pregnant women. Two reviewers assessed independently the titles and abstracts of all search results and full texts of potentially eligible studies reporting original data for maternal/fetal/infant death, preterm birth, fetal growth outcomes, fetal/congenital anomalies, fetal/child neurodevelopment and/or maternal adverse events. We ascertained each study's risk of bias using validated instruments and assessed the strength

SUBMITTER: Zedler BK 

PROVIDER: S-EPMC5129590 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature