Toll-like receptor 4 mutation suppresses hyperhomocysteinemia-induced hypertension.

ABSTRACT: Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is ubiquitously expressed in all cell types of the vasculature. TLR-4 activation has been known to promote inflammation that has been associated with the pathogenesis of hypertension. In this study we hypothesize that HHcy induces hypertension by TLR-4 activation, which promotes inflammatory cytokine (IL-1β, IL-6, and TNF-α) upregulation and initiation of mitochondria-dependent apoptosis, leading to cell death and chronic vascular inflammation. To test this hypothesis, we used C57BL/6J (WT) mice, cystathionine β-synthase (CBS)-deficient (CBS^+/-) mice with genetic mild HHcy, C3H/HeJ (C3H) mice with TLR-4 mutation,

SUBMITTER: Familtseva A 

PROVIDER: S-EPMC5129755 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature