No association of CpG island methylator phenotype and colorectal cancer survival: population-based study.

ABSTRACT:

Background

Previous studies have shown adverse effects of CpG island methylator phenotype (CIMP) on colorectal cancer (CRC) prognosis. However, sample sizes were often limited and only few studies were able to adjust for relevant molecular features associated with CIMP. The aim of this study was to investigate the impact of CIMP on CRC survival in a large population-based study with comprehensive adjustment.

Methods

The CIMP status and other molecular tumour features were analysed in 1385 CRC patients diagnosed between 2003 and 2010. Detailed information were obtained from standardised personal interviews and medical records. During follow-up (median: 4.9 years), we assessed vital status, cause of death and therapy details. Cox proportional hazard regression models were used

SUBMITTER: Jia M 

PROVIDER: S-EPMC5129826 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature