Reproductive and hormonal factors in relation to survival and platinum resistance among ovarian cancer cases.

ABSTRACT:

Background

Ovarian cancer survival is poor, particularly for platinum-resistant cases. The previous literature on pre-diagnostic reproductive factors and ovarian cancer survival has been mixed. Therefore, we evaluated pre-diagnostic reproductive and hormonal factors with overall survival and, additionally, platinum-chemotherapy resistance.

Methods

We followed 1649 invasive epithelial ovarian cancer cases who were enrolled between 1992 and 2008 for overall mortality within the New England Case-Control Study and abstracted chemotherapy data on a subset (n=449). We assessed pre-diagnostic reproductive and hormonal factors during in-person interviews. We calculated hazard ratios (HRs) using Cox-proportional hazards models.

Results

We observed 911 all-cause deaths among 16

SUBMITTER: Shafrir AL 

PROVIDER: S-EPMC5129827 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature