Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread.

ABSTRACT: High grade serous ovarian cancer (HGSOC) is among the most deadly malignancies in women, frequently involving peritoneal tumor spread. Understanding molecular mechanisms of peritoneal metastasis is essential to develop urgently needed targeted therapies. We described two peritoneal tumor spread types in HGSOC apparent during surgery: miliary (numerous millet-sized implants) and non-miliary (few big, bulky implants). The former one is defined by a more epithelial-like tumor cell characteristic with less immune cell reactivity and with significant worse prognosis, even if corrected for typical clinicopathologic factors.23 HGSOC patients were enrolled in this study. Isolated tumor cells from fresh tumor tissues of ovarian and peritoneal origin and from ascites were used for ribosomal RNA depl

SUBMITTER: Bachmayr-Heyda A 

PROVIDER: S-EPMC5129959 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature