Differential association for N-acetyltransferase 2 genotype and phenotype with bladder cancer risk in Chinese population.

ABSTRACT:

Background

N-acetyltransferase 2 (NAT2) is involved in both carcinogen detoxification through hepatic N-acetylation and carcinogen activation through local O-acetylation. NAT2 slow acetylation status is significantly associated with increased bladder cancer risk among European populations, but its association in Asian populations is inconclusive.

Methods

NAT2 acetylation status was determined by both single nucleotide polymorphisms (SNPs) and caffeine metabolic ratio (CMR), in a population-based study of 494 bladder cancer patients and 507 control subjects in Shanghai, China.

Results

The CMR, a functional measure of hepatic N-acetylation, was significantly reduced in a dose-dependent manner among both cases and controls possessing the SNP-inferred NAT2 slow acetylatio

SUBMITTER: Quan L 

PROVIDER: S-EPMC5129988 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature