TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer.

ABSTRACT:

Objective

To explore the expression feature and biological functions of TREM-1 on tumor-associated macrophages (TAMs) in lung cancer.

Results

The levels of TREM-1 on tissue-infiltrating monocytes/macrophage from tumor nest were significantly lower than those from nonturmor tissue or peripheral blood samples. Clinical analysis indicated that the levels of TREM-1-related TAMs were significantly decreased during cancer stages progression. The tumor-bearing mouse model further confirmed that the expression of TREM-1 on TAMs was significantly decreased with tumor growth. In addition, we found the activation of TREM-1 could significantly enhance the secretion of IL-1β by TAM in vitro. Furthermore, T-bet but not Eomes was found to be the key transcription factor for the TREM-1 expr

SUBMITTER: Zhang G 

PROVIDER: S-EPMC5130024 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature