Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer.

ABSTRACT: HER-2 positive tumors are among the most aggressive subtypes of breast cancer and are frequently associated with metastasis and poor outcome. As with other aggressive subtypes of breast cancer, these tumors are associated with abnormally high expression of galectin-7 (gal-7), which confers metastatic breast tumor cells with increased invasive behavior. Although previous studies in the rat model of breast tumorigenesis have shown that gal-7 is also increased in primary breast tumor, its contribution to the development of the primary breast tumors remains unclear. In the present work, we have used genetically-engineered gal-7-deficient mice to examine the role of gal-7 in the development of the mammary gland and of breast cancer. Using histological and immunohistological analysis of whole ma

SUBMITTER: Grosset AA 

PROVIDER: S-EPMC5130216 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature