Joint Profiling of miRNAs and mRNAs Reveals miRNA Mediated Gene Regulation in the Gottingen Minipig Obesity Model.

ABSTRACT: Obesity and its comorbidities are an increasing challenge for both affected individuals and health care systems, worldwide. In obese individuals, perturbation of expression of both protein-coding genes and microRNAs (miRNA) are seen in obesity-relevant tissues (i.e. adipose tissue, liver and skeletal muscle). miRNAs are small non-coding RNA molecules which have important regulatory roles in a wide range of biological processes, including obesity. Rodents are widely used animal models for human diseases including obesity. However, not all research is applicable for human health or diseases. In contrast, pigs are emerging as an excellent animal model for obesity studies, due to their similarities in their metabolism, their digestive tract and their genetics, when compared to humans. The Gött

SUBMITTER: Mentzel CM 

PROVIDER: S-EPMC5130236 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature