Human Lung Tissue Transcriptome: Influence of Sex and Age.

ABSTRACT:

Background

Sex and age strongly influence the pathophysiology of human lungs, but scarce information is available about their effects on pulmonary gene expression.

Methods

We followed a discovery-validation strategy to identify sex- and age-related transcriptional differences in lung.

Results

We identified transcriptional profiles significantly associated with sex (215 genes; FDR < 0.05) and age at surgery (217 genes) in non-involved lung tissue resected from 284 lung adenocarcinoma patients. When these profiles were tested in three independent series of non-tumor lung tissue from an additional 1,111 patients, we validated the association with sex and age for 25 and 22 genes, respectively. Among the 17 sex-biased genes mapping on chromosome X, 16 have been reported to

SUBMITTER: Dugo M 

PROVIDER: S-EPMC5130276 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature