Compound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia.

ABSTRACT: The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated in a rat model of acute myocardial ischemia induced by isoproterenol (ISO) and administrated with CDDP using a metabolomics platform. Our data revealed that the ISO-induced animal model showed obvious myocardial injury, decreased energy production, and a marked change in metabolomic patterns in plasma and heart tissue. CDDP pretreatment increased energy production, ameliorated biochemical indices, modulated the changes and metabolomic pattern induced by ISO, especially in heart tissue. For the first time, we found that ISO induced myocardial ischemia was accomplished with a reduced fatt

SUBMITTER: Guo J 

PROVIDER: S-EPMC5131350 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature