A previously unreported impact of a PLA2G7 gene polymorphism on the plasma levels of lipoprotein-associated phospholipase A2 activity and mass.

ABSTRACT: Lipoprotein-associated phospholipase A2 (Lp-PLA₂) levels are associated with the development of atherosclerosis. We aimed to assess the genetic determinants of Lp-PLA₂ activity and mass by genotyping multiple polymorphisms in PLA2G7, the gene encoding Lp-PLA₂, among 1258 participants from the Chinese Multi-provincial Cohort Study-Beijing Project. The Sequenom MassARRAY system, Taqman assay and direct sequencing were adopted. For the first time, the rs13218408 polymorphism was found to be significantly associated with reduced Lp-PLA₂ levels. We also confirmed the significant association of previously validated polymorphisms (rs1421378, rs1805018, rs16874954 and rs2216465), even after adjusting for traditional cardiovascular risk factors and for Bo

SUBMITTER: Qi Y 

PROVIDER: S-EPMC5131362 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature