Ontology highlight
ABSTRACT:
SUBMITTER: Clayton HW
PROVIDER: S-EPMC5131369 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cell reports 20161101 8
Using a transgenic mouse model to express MafA, Pdx1, and Neurog3 (3TF) in a pancreatic acinar cell- and doxycycline-dependent manner, we discovered that the outcome of transcription factor-mediated acinar to β-like cellular reprogramming is dependent on both the magnitude of 3TF expression and on reprogramming-induced inflammation. Overly robust 3TF expression causes acinar cell necrosis, resulting in marked inflammation and acinar-to-ductal metaplasia. Generation of new β-like cells requires l ...[more]