Effects of Na⁺ Current and Mechanogated Channels in Myofibroblasts on Myocyte Excitability and Repolarization.

ABSTRACT: Fibrotic remodeling, characterized by fibroblast phenotype switching, is often associated with atrial fibrillation and heart failure. This study aimed to investigate the effects on electrotonic myofibroblast-myocyte (Mfb-M) coupling on cardiac myocytes excitability and repolarization of the voltage-gated sodium channels (VGSCs) and single mechanogated channels (MGCs) in human atrial Mfbs. Mathematical modeling was developed from a combination of (1) models of the human atrial myocyte (including the stretch activated ion channel current, I_SAC) and Mfb and (2) our formulation of currents through VGSCs (I_{Na_Mfb}) and MGCs (I_{MGC_Mfb}) based upon experimental findings. The effects of changes in the intercellular coupling conductance, the numbe

SUBMITTER: Zhan H 

PROVIDER: S-EPMC5131562 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature