Potassium channel KIR4.1 as an immune target in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system. Many findings suggest that the disease has an autoimmune pathogenesis; the target of the immune response is not yet known.

Methods

We screened serum IgG from persons with multiple sclerosis to identify antibodies that are capable of binding to brain tissue and observed specific binding of IgG to glial cells in a subgroup of patients. Using a proteomic approach focusing on membrane proteins, we identified the ATP-sensitive inward rectifying potassium channel KIR4.1 as the target of the IgG antibodies. We used a multifaceted validation strategy to confirm KIR4.1 as a target of the autoantibody response in multiple sclerosis and to show its potential pathogenicity in viv

SUBMITTER: Srivastava R 

PROVIDER: S-EPMC5131800 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature