The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences.

ABSTRACT: Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research, have the largest natural geographic distribution of any nonhuman primate, and have been the focus of much evolutionary and behavioral investigation. Consequently, rhesus macaques are one of the most thoroughly studied nonhuman primate species. However, little is known about genome-wide genetic variation in this species. A detailed understanding of extant genomic variation among rhesus macaques has implications for the use of this species as a model for studies of human health and disease, as well as for evolutionary population genomics. Whole-genome sequencing analysis of 133 rhesus macaques revealed more than 43.7 million single-nucleotide variants, including thousands predicted to alter pro

SUBMITTER: Xue C 

PROVIDER: S-EPMC5131817 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature