MTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.

ABSTRACT: Neurogenesis is the process of neuron generation, which occurs not only during embryonic development but also in restricted niches postnatally. One such region is called the subventricular zone (SVZ), which gives rise to new neurons in the olfactory bulb (OB). Neurons that are born postnatally migrate through more complex territories and integrate into fully functional circuits. Therefore, differences in the differentiation of embryonic and postnatally born neurons may exist. Dendritogenesis is an important process for the proper formation of future neuronal circuits. Dendritogenesis in embryonic neurons cultured in vitro was shown to depend on the mammalian target of rapamycin (mTOR). Still unknown, however, is whether mTOR could regulate the dendritic arbor morphology of SVZ-derived post

SUBMITTER: Skalecka A 

PROVIDER: S-EPMC5132010 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature