Epigenetic Signatures of Salivary Gland Inflammation in Sjogren's Syndrome.

ABSTRACT:

Objective

Sjögren's syndrome (SS) is a complex multisystem autoimmune disease that results in progressive destruction of the exocrine glands. The purpose of this study was to characterize epigenetic changes in affected gland tissue and describe the relationship of these changes to known inflammatory processes.

Methods

A genome-wide DNA methylation study was performed on human labial salivary gland (LSG) biopsy samples obtained from 28 female members of the Sjögren's International Collaborative Clinical Alliance (SICCA) Registry. Gland tissue was methylotyped using the Illumina HumanMethylation450 BeadChip platform, followed by rigorous probe-filtering and data-normalization procedures.

Results

A genome-wide case-control study of 26 of the 28 subjects revealed 7,820 di

SUBMITTER: Cole MB 

PROVIDER: S-EPMC5132022 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature