Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis.

ABSTRACT: Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian randomisation analysis to investigate the causal effects of coffee consumption on prostate cancer risk and progression. We used two genetic variants robustly associated with caffeine intake (rs4410790 and rs2472297) as proxies for coffee consumption in a sample of 46,687 men of European ancestry from 25 studies in the PRACTICAL consortium. Associations between genetic variants and prostate cancer case status, stage and grade were assessed by logistic regression and with all-cause and prostate cancer-specific mortality using Cox proportional hazards regression. There wa

SUBMITTER: Taylor AE 

PROVIDER: S-EPMC5132137 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature