A common bacterial metabolite elicits prion-based bypass of glucose repression.

ABSTRACT: Robust preference for fermentative glucose metabolism has motivated domestication of the budding yeast Saccharomyces cerevisiae. This program can be circumvented by a protein-based genetic element, the [GAR⁺] prion, permitting simultaneous metabolism of glucose and other carbon sources. Diverse bacteria can elicit yeast cells to acquire [GAR⁺], although the molecular details of this interaction remain unknown. Here we identify the common bacterial metabolite lactic acid as a strong [GAR⁺] inducer. Transient exposure to lactic acid caused yeast cells to heritably circumvent glucose repression. This trait had the defining genetic properties of [GAR⁺], and did not require utilization of lactic acid as a carbon sour

SUBMITTER: Garcia DM 

PROVIDER: S-EPMC5132342 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature