Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets.

ABSTRACT: Human NK cells play critical roles in human host defense, particularly the control of viral infection and malignancy, and patients with congenital immunodeficiency affecting NK cell function or number can suffer from severe illness. The importance of NK cell function is particularly underscored in patients with primary immunodeficiency in which NK cells are the primary or sole affected population (NK cell deficiency, NKD). While NKD may lead to the absence of NK cells, we are also gaining an increasing appreciation of the effect that NKD may have on the generation of specific NK cell subsets. In turn, this leads to improved insights into the requirements for human NK cell subset generation, as well as their importance in immune homeostasis. The presence of inherently abnormally developed o

SUBMITTER: Mace EM 

PROVIDER: S-EPMC5133264 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature