Guanylate-binding protein 5 is a marker of interferon-γ-induced classically activated macrophages.

ABSTRACT: Macrophage activation is the main immunological process occurring during the development of several diseases, and the heterogeneity of macrophage activation or differentiation has been suggested to be involved in disease progression. In the present study, we attempted to identify molecules specifically expressed on human classically activated macrophages (M1) to investigate the significance of the M1-like phenotype in human diseases. Human monocyte-derived macrophages were differentiated into M1, M2a, M2b and M2c phenotypes, and also M1(-) (the M1 phenotype differentiated with interferon-γ) to eliminate the strong effects of lipopolysaccharides (LPS) on the gene expression profile. The gene expression profiles of those macrophage phenotypes were analyzed by a cDNA microarray analysis and w

SUBMITTER: Fujiwara Y 

PROVIDER: S-EPMC5133363 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature