Integrated computational approach to the analysis of RNA-seq data reveals new transcriptional regulators of psoriasis.

ABSTRACT: Psoriasis is a common inflammatory skin disease with complex etiology and chronic progression. To provide novel insights into the regulatory molecular mechanisms of the disease, we performed RNA sequencing analysis of 14 pairs of skin samples collected from patients with psoriasis. Subsequent pathway analysis and extraction of the transcriptional regulators governing psoriasis-associated pathways was executed using a combination of the MetaCore Interactome enrichment tool and the cisExpress algorithm, followed by comparison to a set of previously described psoriasis response elements. A comparative approach allowed us to identify 42 core transcriptional regulators of the disease associated with inflammation (NFκB, IRF9, JUN, FOS, SRF), the activity of T cells in psoriatic lesions (STAT6, F

SUBMITTER: Zolotarenko A 

PROVIDER: S-EPMC5133374 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature