SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells.

ABSTRACT: The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh), which plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profiling during the differentiation of embryonic stem cells to neural progenitor cells, here we report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6)-that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this different

SUBMITTER: Benabdallah NS 

PROVIDER: S-EPMC5133441 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature