Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.

ABSTRACT: T-cell identity is established by the expression of a clonotypic T-cell receptor (TCR), generated by somatic rearrangement of TCRα and β genes. The properties of the TCR determine both the degree of self-reactivity and the repertoire of antigens that can be recognized. For CD8 T cells, the relationship between TCR identity-hence reactivity to self-and effector function(s) remains to be fully understood and has rarely been explored outside of the H-2^b haplotype. We measured the affinity of three structurally distinct CD8 T-cell-derived TCRs that recognize the identical H-2 L^d-restricted epitope, derived from the Rop7 protein of Toxoplasma gondii We used CD8 T cells obtained from mice generated by somatic cell nuclear transfer as the closest approximation of primary T c

SUBMITTER: Swee LK 

PROVIDER: S-EPMC5133449 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature