Reoptimization of Intensity Modulated Proton Therapy Plans Based on Linear Energy Transfer.

ABSTRACT:

Purpose

We describe a treatment plan optimization method for intensity modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume while limiting degradation of the best possible physical dose distribution.

Methods and materials

To allow fast optimization based on dose and LET, a GPU-based Monte Carlo code was extended to provide dose-averaged LET in addition to dose for all pencil beams. After optimizing an initial IMPT plan based on physical dose, a prioritized optimization scheme is used to modify the LET distribution while constraining the physical dose objectives to values close to the initial plan. The LET optimization step is performed based on objective functions evaluated for

SUBMITTER: Unkelbach J 

PROVIDER: S-EPMC5133459 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature