Joint analysis of multiple blood pressure phenotypes in GAW19 data by using a multivariate rare-variant association test.

ABSTRACT:

Introduction

Large-scale sequencing studies often measure many related phenotypes in addition to the genetic variants. Joint analysis of multiple phenotypes in genetic association studies may increase power to detect disease-associated loci.

Methods

We apply a recently developed multivariate rare-variant association test to the Genetic Analysis Workshop 19 data in order to test associations between genetic variants and multiple blood pressure phenotypes simultaneously. We also compare this multivariate test with a widely used univariate test that analyzes phenotypes separately.

Results

The multivariate test identified 2 genetic variants that have been previously reported as associated with hypertension or coronary artery disease. In addition, our region-based analyses

SUBMITTER: Sun J 

PROVIDER: S-EPMC5133485 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature