Impact of schizophrenia on anterior and posterior hippocampus during memory for complex scenes.

ABSTRACT:

Objectives

Hippocampal dysfunction has been proposed as a mechanism for memory deficits in schizophrenia. Available evidence suggests that the anterior and posterior hippocampus could be differentially affected. Accordingly, we used fMRI to test the hypothesis that activity in posterior hippocampus is disproportionately reduced in schizophrenia, particularly during spatial memory retrieval.

Methods

26 healthy participants and 24 patients with schizophrenia from the UC Davis Early Psychosis Program were studied while fMRI was acquired on a 3 Tesla Siemens scanner. During encoding, participants were oriented to critical items through questions about item features (e.g., "Does the lamp have a square shade?") or spatial location (e.g., "Is the lamp on the table next to the couch

SUBMITTER: Ragland JD 

PROVIDER: S-EPMC5133646 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature