Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study.

ABSTRACT:

Purpose

MRI has become an essential tool for prion disease diagnosis. However there exist only a few serial MRI studies of prion patients, and these mostly used whole brain summary measures or region of interest based approaches. We present here the first longitudinal voxel-based morphometry (VBM) study in prion disease. The aim of this study was to systematically characterise progressive atrophy in patients with prion disease and identify whether atrophy in specific brain structures correlates with clinical assessment.

Methods

Twenty-four prion disease patients with early stage disease (3 sporadic, 2 iatrogenic, 1 variant and 18 inherited CJD) and 25 controls were examined at 3T with a T1-weighted 3D MPRAGE sequence at multiple time-points (2-6 examinations per subject, int

SUBMITTER: De Vita E 

PROVIDER: S-EPMC5133666 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature