Ontology highlight
ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC5133708 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nature communications 20161125
The nucleolus has been recently described as a stress sensor. The nucleoplasmic translocation of nucleolar protein nucleophosmin (NPM1) is a hallmark of nucleolar stress; however, the causes of this translocation and its connection to p53 activation are unclear. Using single live-cell imaging and the redox biosensors, we demonstrate that nucleolar oxidation is a general response to various cellular stresses. During nucleolar oxidation, NPM1 undergoes S-glutathionylation on cysteine 275, which tr ...[more]