Integrated Computational Approach for Virtual Hit Identification against Ebola Viral Proteins VP35 and VP40.

ABSTRACT: The Ebola virus (EBOV) has been recognised for nearly 40 years, with the most recent EBOV outbreak being in West Africa, where it created a humanitarian crisis. Mortalities reported up to 30 March 2016 totalled 11,307. However, up until now, EBOV drugs have been far from achieving regulatory (FDA) approval. It is therefore essential to identify parent compounds that have the potential to be developed into effective drugs. Studies on Ebola viral proteins have shown that some can elicit an immunological response in mice, and these are now considered essential components of a vaccine designed to protect against Ebola haemorrhagic fever. The current study focuses on chemoinformatic approaches to identify virtual hits against Ebola viral proteins (VP35 and VP40), including protein binding site

SUBMITTER: Mirza MU 

PROVIDER: S-EPMC5133775 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature