Neuroglobin, a Factor Playing for Nerve Cell Survival.

ABSTRACT: Cell death represents the final outcome of several pathological conditions of the central nervous system and available evidence suggests that in both acute injuries and neurodegenerative diseases it is often associated with mitochondrial dysfunction. Thus, the possibility to prevent mitochondrial events involved in cell death might represent efficient tools to limit neuronal damage. In recent years, increased attention has been paid to the endogenous protein neuroglobin, since accumulating evidence showed that its high expression was associated with preserved mitochondrial function and to an increased survival of nerve cells in vitro and in vivo in a variety of experimental models of cell insult. The biological and structural features of neuroglobin and the mitochondria-related mechanisms

SUBMITTER: Guidolin D 

PROVIDER: S-EPMC5133818 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature