Transition Metal Intercalators as Anticancer Agents-Recent Advances.

ABSTRACT: The diverse anticancer utility of cisplatin has stimulated significant interest in the development of additional platinum-based therapies, resulting in several analogues receiving clinical approval worldwide. However, due to structural and mechanistic similarities, the effectiveness of platinum-based therapies is countered by severe side-effects, narrow spectrum of activity and the development of resistance. Nonetheless, metal complexes offer unique characteristics and exceptional versatility, with the ability to alter their pharmacology through facile modifications of geometry and coordination number. This has prompted the search for metal-based complexes with distinctly different structural motifs and non-covalent modes of binding with a primary aim of circumventing current clinical limi

SUBMITTER: Deo KM 

PROVIDER: S-EPMC5133819 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature