Prediction of Protein-Protein Interactions by Evidence Combining Methods.

ABSTRACT: Most cellular functions involve proteins' features based on their physical interactions with other partner proteins. Sketching a map of protein-protein interactions (PPIs) is therefore an important inception step towards understanding the basics of cell functions. Several experimental techniques operating in vivo or in vitro have made significant contributions to screening a large number of protein interaction partners, especially high-throughput experimental methods. However, computational approaches for PPI predication supported by rapid accumulation of data generated from experimental techniques, 3D structure definitions, and genome sequencing have boosted the map sketching of PPIs. In this review, we shed light on in silico PPI prediction methods that integrate evidence from multiple s

SUBMITTER: Chang JW 

PROVIDER: S-EPMC5133940 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature