MiR-125b modulates megakaryocyte maturation by targeting the cell-cycle inhibitor p19^INK4D.

ABSTRACT: A better understanding of the mechanisms involved in megakaryocyte maturation will facilitate the generation of platelets in vitro and their clinical applications. A microRNA, miR-125b, has been suggested to have important roles in the self-renewal of megakaryocyte-erythroid progenitors and in platelet generation. However, miR-125b is also critical for hematopoietic stem cell self-renewal. Thus, the function of miR-125b and the complex signaling pathways regulating megakaryopoiesis remain to be elucidated. In this study, an attentive examination of the endogenous expression of miR-125b during megakaryocyte differentiation was performed. Accordingly, the differentiation of hematopoietic stem cells requires the downregulation of miR-125b, whereas megakaryocyte determination and maturation sy

SUBMITTER: Qu M 

PROVIDER: S-EPMC5133966 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature