A new mechanism for spatial pattern formation via lateral and protrusion-mediated lateral signalling.

ABSTRACT: Tissue organization and patterning are critical during development when genetically identical cells take on different fates. Lateral signalling plays an important role in this process by helping to generate self-organized spatial patterns in an otherwise uniform collection of cells. Recent data suggest that lateral signalling can be mediated both by junctional contacts between neighbouring cells and via cellular protrusions that allow non-neighbouring cells to interact with one another at a distance. However, it remains unclear precisely how signalling mediated by these distinct types of cell-cell contact can physically contribute to the generation of complex patterns without the assistance of diffusible morphogens or pre-patterns. To explore this question, in this work we develop a model

SUBMITTER: Hadjivasiliou Z 

PROVIDER: S-EPMC5134009 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature