Autosomal genetic control of human gene expression does not differ across the sexes.

ABSTRACT:

Background

Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, and has largely been explored by examining the contribution of genotype-by-sex interactions to variation in gene expression.

Results

In this study, we use data from a mixture of pedigree and unrelated individuals with verified European ancestry to investigate the sex-specific genetic architecture of gene expression measured in whole blood across n=1048 males and n=1005 females by treating gene expression intensities in the sexes as two distinct traits and estimating the genetic correlation (r _G) between them. These correlations measure the similarit

SUBMITTER: Kassam I 

PROVIDER: S-EPMC5134098 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature