Bone morphogenetic protein-2-mediated pain and inflammation in a rat model of posterolateral arthrodesis.

ABSTRACT:

Background

Bone morphogenetic protein-2 (BMP-2) is a pleiotropic, secreted molecule with diverse effects. The potent ability of BMP-2 to stimulate bone growth prompted its widespread clinical use for arthrodesis (spine fusion). However, elevated post-operative pain in patients treated with BMP-2 has been increasingly reported. Determining whether BMP-2 induces pain directly or whether it induces neuroinflammation, which could lower the threshold for pain, is important for developing therapeutic interventions. We therefore modeled the clinical use of BMP-2 for posterior lumbar fusion by implanting absorbable collagen sponges soaked with either recombinant human BMP-2 (rhBMP-2) or vehicle above the L4-L5 transverse processes of rat spine.

Results

Using microarray analysis we f

SUBMITTER: Mitchell K 

PROVIDER: S-EPMC5134101 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature