Chromatin landscapes and genetic risk in systemic lupus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) is a multi-system, complex disease in which the environment interacts with inherited genes to produce broad phenotypes with inter-individual variability. Of 46 single nucleotide polymorphisms (SNPs) shown to confer genetic risk for SLE in recent genome-wide association studies, 30 lie within noncoding regions of the human genome. We therefore sought to identify and describe the functional elements (aside from genes) located within these regions of interest.

Methods

We used chromatin immunoprecipitation followed by sequencing to identify epigenetic marks associated with enhancer function in adult neutrophils to determine whether enhancer-associated histone marks were enriched within the linkage disequilibrium (LD) blocks encompass

SUBMITTER: Hui-Yuen JS 

PROVIDER: S-EPMC5134118 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature