Comparative genomics of Beauveria bassiana: uncovering signatures of virulence against mosquitoes.

ABSTRACT:

Background

Entomopathogenic fungi such as Beauveria bassiana are promising biological agents for control of malaria mosquitoes. Indeed, infection with B. bassiana reduces the lifespan of mosquitoes in the laboratory and in the field. Natural isolates of B. bassiana show up to 10-fold differences in virulence between the most and the least virulent isolate. In this study, we sequenced the genomes of five isolates representing the extremes of low/high virulence and three RNA libraries, and applied a genome comparison approach to uncover genetic mechanisms underpinning virulence.

Results

A high-quality, near-complete genome assembly was achieved for the highly virulent isolate Bb8028, which was compared to the assemblies of the four other isolates. Whole genome analysis showed

SUBMITTER: Valero-Jimenez CA 

PROVIDER: S-EPMC5134283 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature