A multicomponent approach for the preparation of homoallylic alcohols.

ABSTRACT: Here we report the in situ generation of transient allylic boronic species, by reacting TMSCHN₂ and E-vinyl boronic acids, followed by their subsequent trapping with aldehydes as electrophiles to yield homoallylic alcohols. This metal-free reaction was initially discovered by the use of a flow chemistry approach to generate a variety of homoallylic alcohols in a straightforward fashion and then transferred to a batch protocol.

SUBMITTER: Poh JS 

PROVIDER: S-EPMC5134730 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature