Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2).

ABSTRACT:

Background and purpose

Therapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic hypothermia for acute ischemic stroke is safe and feasible in pilot trials. We designed a study protocol to provide safer, faster therapeutic hypothermia in stroke patients.

Methods

Safety procedures and 4°C saline infusions for faster cooling were added to the ICTuS trial (Intravascular Cooling in the Treatment of Stroke) protocol. A femoral venous intravascular cooling catheter after intravenous recombinant tissue-type plasminogen activator in eligible patients provided 24 hours cooling followed by a 12-hour rewarm. Serial safety assessments and imaging were performed. The primary end point was 3-month m

SUBMITTER: Lyden P 

PROVIDER: S-EPMC5134910 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature