Changes in regional body composition over 8 years in a randomized lifestyle trial: The look AHEAD study.

ABSTRACT:

Objective

To test the hypothesis that an 8-year intensive lifestyle intervention (ILI) suppresses aging-dependent changes in regional lean mass (LM) and fat mass (FM) among people with overweight/obesity and type 2 diabetes.

Methods

Regional body composition was measured by dual-energy X-ray absorptiometry within a subset of 1,019 volunteers (45-75 years old) in the Look AHEAD study randomized to ILI or diabetes support and education (DSE). The ILI goal was to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake.

Results

Over 8 years, the DSE group exhibited a linear loss of LM and FM. During year 1, the ILI group lost LM and FM. Between years 1 and 8, the ILI group regained most FM in all regions; regional LM converged w

SUBMITTER: Pownall HJ 

PROVIDER: S-EPMC5134917 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature