Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs.

ABSTRACT: Many cell signaling systems, including the yeast pheromone response system, exhibit "dose-response alignment" (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including "push-pull" mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to matc

SUBMITTER: Andrews SS 

PROVIDER: S-EPMC5134923 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature