Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques.

ABSTRACT:

Background

Zika virus (ZIKV; Flaviviridae, Flavivirus) was declared a public health emergency of international concern by the World Health Organization (WHO) in February 2016, because of the evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome in adults and congenital birth defects including microcephaly in the developing fetus. Because development of a ZIKV vaccine is a top research priority and because the genetic and antigenic variability of many RNA viruses limits the effectiveness of vaccines, assessing whether immunity elicited against one ZIKV strain is sufficient to confer broad protection against all ZIKV strains is critical. Recently, in vitro studies demonstrated that ZIKV likely circulates as a single serotype. Here, we dem

SUBMITTER: Aliota MT 

PROVIDER: S-EPMC5135040 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature