Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.

ABSTRACT: Psoriasis patients are at increased risk of heart attack and stroke and have elevated MRP8/14 levels that predict heart attack. The KC-Tie2 psoriasiform mouse model exhibits elevated MRP8/14 and is prothrombotic. Mrp14^-/- mice, in contrast, are protected from thrombosis, but, surprisingly, KC-Tie2xMrp14^-/- mice remain prothrombotic. Treating KC-Tie2xMrp14^-/- mice with anti-IL-23p19 antibodies reversed the skin inflammation, improved thrombosis, and decreased IL-6. In comparison, IL-6 deletion from KC-Tie2 animals improved thrombosis despite sustained skin inflammation, suggesting that thrombosis improvements following IL-23 inhibition occur secondary to IL-6 decreases. Psoriasis patient skin has elevated IL-6 and IL-6 receptor is presen

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5135273 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature