Structural basis for DNA recognition by STAT6.

ABSTRACT: STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations in STAT6-mediated signaling are linked to development of asthma and diseases of the immune system. In addition, STAT6 remains constitutively active in multiple types of cancer. Therefore, targeting STAT6 is an attractive proposition for treating related diseases. Although a lot is known about the role of STAT6 in transcriptional regulation, molecular details on how STAT6 recognizes and binds specific segments of DNA to exert its function are not clearly understood. Here, we report the crystal structures of a homodimer of phosphorylated STAT6 core fragment (STAT6^CF) alone and bound with the N3 and N4 DNA binding site. Analysis of the stru

SUBMITTER: Li J 

PROVIDER: S-EPMC5135355 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature