Changes in mammary histology and transcriptome profiles by low-dose exposure to environmental phenols at critical windows of development.

ABSTRACT: Exposure to environmental chemicals has been linked to altered mammary development and cancer risk at high doses using animal models. Effects at low doses comparable to human exposure remain poorly understood, especially during critical developmental windows. We investigated the effects of two environmental phenols commonly used in personal care products - methyl paraben (MPB) and triclosan (TCS) - on the histology and transcriptome of normal mammary glands at low doses mimicking human exposure during critical windows of development. Sprague-Dawley rats were exposed during perinatal, prepubertal and pubertal windows, as well as from birth to lactation. Low-dose exposure to MPB and TCS induced measurable changes in both mammary histology (by Masson's Trichrome Stain) and transcriptome (by m

SUBMITTER: Gopalakrishnan K 

PROVIDER: S-EPMC5135583 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature